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United States Department of Agriculture

Agricultural Research Service

Research Project: MOLECULAR, CELLULAR, AND REGULATORY ASPECTS OF OBESITY DEVELOPMENT IN CHILDREN

Location: Children's Nutrition Research Center

Title: Parenteral lipid fatty acid composition directly determines the fatty acid composition of red blood cell and brain lipids in preterm pigs

Authors
item Stoll, Barbara -
item Vlaardingerbroek, Hester -
item Benight, Nancy -
item Olutoye, Oluyinka -
item Van Goudoever, Johannes -
item Heird, William -
item Burrin, Douglas

Submitted to: Pediatric Academic Society
Publication Type: Abstract Only
Publication Acceptance Date: April 14, 2011
Publication Date: April 30, 2011
Citation: Stoll, B., Vlaardingerbroek, H., Benight, N.M., Olutoye, O., Van Goudoever, J., Heird, W., Burrin, D.G. 2011. Parenteral lipid fatty acid composition directly determines the fatty acid composition of red blood cell and brain lipids in preterm pigs [abstract]. In: Proceedings of the 2011 Annual Conference of the Pediatric Academic Society and the Asian Society for Pediatric Research. Session: Neonatal fetal nutrition and metabolism II, April 30-May 3, 2011, Denver, Colorado. 3670.5.

Technical Abstract: Studies in enterally-fed infants have shown a positive effect of n-3 long-chain polyunsaturated fatty acid (LCPUFA) supplementatin on neurodevelopment. The effect of n-3 LCPUFA in fish oil-based parenteral (PN) lipid emulsions on neuronal tissues of PN-fed preterm infants is unknown. The objective of this study was to test whether different PN lipid emulsions directly modify the tissue composition and metabolism of lipids in preterm pigs. Preterm pigs bearing venous and arterial catheters received 1 of 4 treatments (7-14 pigs/group): PN + soybean oil (Intralipid, IL), PN + fish (Omegaven, OV), PN + oil mixture w/soybean (30 percent)-coconut (30 percent)-olive (25 percent)-fish (15 percent) (SMOFlipid, SL), milk formula fed enterally (EN). On d 11, pigs were subjected to (13)C-palmitate oxidation and whole-body respiratory calorimetry measures; on d 14 blood and tissues were collected for analysis of lipid composition. Heat and (13)CO2 production from (13)C palmitate, respiratory quotient (RQ), serum cholesterol, triglycerides, and VLDL were not different between PN groups. However, RQ was higher in OV than EN. The intake and tissue concentration of essential LCPUFA, including (18:2)n-6 and (18:3)n-3, were higher in IL vx either OV or SL. The intake and tissue concentrations of the LCPUFA, including (20:5)n-3 and (22:6)n-3, were higher in OV and SL vs IL groups. The concentrations of these latter n-3 LCPUFA tend to be higher in OV than in the SL group.) In conclusion, the chronic parenteral infusion of fish oil-containing lipid emulsions results in higher proportions of n-3 LCPUFA in blood, liver and brain of preterm pigs. The enrichment of tissue with n-3 LCPUFA may have benefical metabolic and functional actions in preterm infants.

Last Modified: 8/21/2014
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