Technical Abstract: Medusahead is an exotic annual grass that is decreasing livestock forage production, increasing wildfire frequency, and reducing biodiversity in sagebrush rangelands. The spread of medusahead should be reduced by treating infestations along roads, increasing or maintaining high perennial bunchgrass abundance, and monitoring for and eradicating small populations. The best control of medusahead is achieved with prescribed burning followed by a fall application of a pre-emergent herbicide. Seeding crested wheatgrass and squirreltail one year after application of a pre-emergent herbicide has been successfully used to revegetate medusahead-invaded sagebrush plant communities. Additional research is needed to determine if native plants can be established and effectively resist re-invasion after medusahead control.