Technical Abstract: Medusahead is an exotic annual grass invading western rangelands. Medusahead invasion is particularly troublesome, because revegetation of invaded areas is difficult. This manuscript synthesizes the literature to provide recommendations for managing medusahead in sagebrush plant communities. Because of the limited success of revegetation, adopting an approach that focuses on preventing new infestations and limiting the expansion of existing infestations has the greatest potential to reduce the future impacts of medusahead. However, there is still a need to revegetate existing medusahead infestations. Recent research suggests that medusahead control may be achieved with prescribed burning followed by a fall application of imazapic. Perennial bunchgrasses are then seeded the fall after imazapic application to revegetate the medusahead infestation. This method is expensive and may not always be successful, thus it is still beneficial to prevent new medusahead infestations. This synthesis can be used to direct management actions and prioritize efforts to reduce the impacts of medusahead.