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United States Department of Agriculture

Agricultural Research Service

Research Project: DETECTION OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY AGENTS IN LIVESTOCK, WILDLIFE, AGRICULTURAL PRODUCTS, AND THE ENVIRONMENT Title: Mass spectrometry and prions: The need to simplify and remove oil from the system

Author
item SILVA, CHRISTOPHER

Submitted to: International News on Fats, Oils and Related Materials
Publication Type: Review Article
Publication Acceptance Date: July 2, 2010
Publication Date: August 25, 2010
Citation: Silva, C.J. 2010. Mass spectrometry and prions: The need to simplify and remove oil from the system. International News on Fats, Oils and Related Materials.21(8):517-520.

Technical Abstract: Transmissible spongiform encephalopathies (TSE)are a set of rare fatal neurological diseases. TSE are characterized by a long latency period, followed by a relatively rapid onset of neurological symptoms that inevitably ends in the death of the host. The hallmark of these diseases is the formation of microscopic holes in the brain (spongiform encephalopathy), which occurs without eliciting an immune response. TSE afflict a number of mammals: sheep (scrapie); goats (scrapie); and deer, elk, and moose (chronic wasting disease: CWD). The human forms of TSE include Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Schein ker (GSS) disease, kuru, fatal familial insomnia (FFI), and variant Creutzfeldt- Jakob disease (vCJD). These are the only known diseases that can be both heritable and transmissible.

Last Modified: 8/27/2014
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