Technical Abstract: The purpose of this study was to develop an antimicrobial bottle coating effective at inhibiting the growth of Salmonella in liquid egg albumen (egg white) and reduce the risk of human Salmonellosis. Four-ounce glass jars were coated with a mixture of polylactic acid (PLA) polymer and antimicrobial compounds containing 100-500 µl allyl isothiocyanate (AIT), 250 mg nisin, 250 mg ZnO nanoparticles per jar, or their combinations. The coated jars contained 100 ml of liquid egg white (LEW) inoculated with a three-strain Salmonella enterica subsp. enterica cocktail at populations of 1000 CFU per ml or 10,000,000 CFU/ml, and stored at 10C for 28 days. The PLA coating with 500 mu AIT completely inactivated 3 and 7 log CFU per ml of Salmonella after 7 and 21 days of storage, respectively. A synergistic bactericidal effect against Salmonella occurred when two or more antimicrobials were used together. The PLA coating with 200 mu AIT in combination with 250 mg nisin reduced Salmonella populations to an undetectable level (<10 CFU/ml) after 21 days of storage, which was equivalent to the coating treatment with 500 µl AIT and more than a 5-log CFU/ml reduction. These data suggest that PLA coatings containing AIT alone or AIT in combination with nisin inactivated salmonellae in LEW.