|Rutherford, Drew -|
|Murphy, Kris -|
Submitted to: Society of Toxicology
Publication Type: Abstract Only
Publication Acceptance Date: November 3, 2009
Publication Date: March 9, 2010
Citation: Hakk, H., Huwe, J.K., Rutherford, D., Murphy, K. 2010. Emerging POPs in edible tissues: ADME study of BDE-47 in chickens. Society of Toxicology Annual Meeting and ToxExpo, March 7-11, 2010, Salt Lake City, UT. Abstract #643. The Toxicologist CD-An official Journal of the Society of Toxicology, Vol. 114, Number S-1, March 2010. Technical Abstract: Studies in mammals have shown that lipophilic tissues such as adipose and skin are the major reservoirs for polybrominated diphenyl ethers (PBDE’s). Because humans commonly consume the skin of chicken, it was of interest to study the metabolic behavior of the most abundant PBDE found in biota, i.e. 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in this production avian species. Single-oral-dose results demonstrated that, as previously shown in rats and mice, BDE-47 was well absorbed from the gut (nearly 61% remained in tissues at 72h), and was distributed both on a %dose basis and a concentration basis to lipophilic tissues, i.e. adipose tissue, skin and GI tract. BDE-47 levels in these tissues were 3-35 times greater than in the edible muscle, and dark meat contained three times more BDE-47 than white meat. Metabolism to free metabolites was less than 1% of the dose, although non-extractables in the excreta amounted to 12% of the dose. Excreted metabolites had undergone a variety of oxidative and debromination events. These results demonstrate that edible chicken tissues may serve as a good route of PBDEs in humans, however, trimming fat and skin may dramatically reduce these exposures.