Technical Abstract: The prevalence of dementia, in particular Alzheimer’s disease, is increasing with the expansion of the older adult population. In the absence of effective therapy, preventive approaches are essential to mitigate this public health problem. Blueberries contain polyphenolic compounds, most prominently anthocyanins, which have been associated with antioxidant, anti-inflammatory, and neuronal signaling effects as well as enhanced metabolic function, key factors in neurodegeneration. We investigated the effects of daily consumption of wild blueberry juice in a sample of older adults with early memory changes. At 12 weeks, we observed enhanced paired associate learning (p = .009) and improved word list recall (p = .04). In addition, there were trends suggesting reduced depressive symptoms (p = .08) and lower glucose levels (p = .10). The findings of this preliminary study suggest that moderate-term blueberry supplementation can induce cognitive benefits. Larger, controlled human trials are indicated to study the preventive potential and mechanisms of effect of blueberry consumption with respect to age-related memory decline and dementia.