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United States Department of Agriculture

Agricultural Research Service

Research Project: ENHANCING GENETIC MERIT OF DAIRY CATTLE THROUGH GENOME SELECTION AND ANALYSIS Title: Information Theoretical Analysis of a Bovine Gene Atlas Reveals Chromosomal Regions with Tissue Specific Gene Expression.

Authors
item Sonstegard, Tad
item Harhay, Gregory
item Alexander, Leeson
item Schroeder, Steven
item Keele, John
item Matukumalli, Lakshmi -
item Bridges, Susan -
item Burgess, Shane -
item Van Tassell, Curtis
item Smith, Timothy

Submitted to: Plant and Animal Genome VX Conference Abstracts
Publication Type: Abstract Only
Publication Acceptance Date: December 31, 2009
Publication Date: January 9, 2010
Citation: Sonstegard, T.S., Harhay, G.P., Alexander, L.J., Schroeder, S.G., Keele, J.W., Matukumalli, L., Bridges, S., Burgess, S., Van Tassell, C.P., Smith, T.P. 2010. Information Theoretical Analysis of a Bovine Gene Atlas Reveals Chromosomal Regions with Tissue Specific Gene Expression. Plant and Animal Genome VX Conference Abstracts.

Technical Abstract: An essential step to understanding the genomic biology of any organism is to comprehensively survey its transcriptome. We present the Bovine Gene Atlas (BGA) a compendium of over 7.2 million unique 20 base Illumina DGE tags representing 100 tissue transcriptomes collected primarily from L1 Dominette, the Hereford cow whose genome was sequenced, her father, and male and female offspring. A GBrowse view of the alignment of the BGA tag data to a genome draft assembly can be examined at http://www.agbase.msstate.edu/bovineatlas, and we provide an overview of how to use this database schema for positional and functional queries. Consistency of the BGA tags with current gene models and demonstration of a novel informational entropy analysis that facilitates recognition of tissue specific expression with respect to chromosomal position will be presented.

Last Modified: 8/22/2014