ARS | Publication request: Decreased insulin sensitivity due to continuous nutrient administration in neonatal pigs

Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: April 1, 2008
Publication Date: May 1, 2009
Citation: Stoll, B., Puiman, P.J., Benight, N., Bauchart, C., Burrin, D.G. 2009. Decreased insulin sensitivity due to continuous nutrient administration in neonatal pigs [abstract]. Journal of Federation of American Societies for Experimental Biology. 23:33.3.

Technical Abstract: Chronic TPN compared to intermittent formula feeding has been shown to induce hepatic insulin resistance and steatosis in neonatal pigs. We hypothesized that the route of feeding (IV vs. enteral) rather than the nature of the diet (elemental vs polymeric) or the feeding regimen (continuous vs intermittent) had contributed to the outcome. Neonatal pigs received one of four feeding regimen for 10-14 d: elemental diet continously IV (TPN), intragastrically (CEN), intermittently intragastrically (IEN), or a milk-based formula intermittently intragastrically (FORM). At the end of the study, insulin sensitivity was examined using hyperinsulinemic-euglycemic clamp technique. The glucose infusion rates required to maintain fasting blood glucose levels were not different between TPN and CEN. IEN was significantly higher than the former and tended to be lower than FORM. Liver weights were 46% higher in TPN compared to the other groups. Hepatic triglycerides (TG) were not different between TPN and CEN, and higher than in IEN and FORM, which were similar. When given continuously, the route of elemental nutrient administration does not affect insulin sensitivity or hepatic TG. Thus, the pattern rather than the route of nutrient administration appears to influence insulin sensitivity.