Technical Abstract: With few exceptions, the diseases that present the greatest risk to food animal production have been largely similar throughout the modern era of veterinary medicine. The current trend of ever - increasing globalization of trade of animals and animal products ensures that agricultural diseases will continue to follow legal trade patterns and illicit transfer of animal materials with increasing rapidity. Global climate changes have already had profound effects on the distribution of veterinary diseases and it is an inevitable reality that continually evolving climatic parameters will further transform the ecology of numerous pathogens. The purpose of this review is to provide an overview of the agricultural diseases which, in recent years, have given cause for concern regarding changes in distribution or severity. Foot – and –mouth disease, avian influenza, and African swine fever continue to be of significant concern. The expected announcement of the global eradication of rinderpest is one of the greatest successes of veterinary preventative medicine; yet peste des petits ruminants still spreads throughout the Middle East and Asia. The spread of novel strains of bluetongue virus across Europe is an ominous indicator that climate change is sure to influence trends in movement of agricultural diseases. Overall, veterinary practitioners and investigators are advised to maintain vigilance against the staple disease threats, but also to always be sufficiently broad-minded to expect the unexpected.