ARS | Publication request: Pathogenicity of a Molecular Clone of Marek's Disease Virus with an Insert of Long Terminal Repeat of Reticuloendotheliosis Virus

Submitted to: American Veterinary Medical Association Abstract
Publication Type: Abstract Only
Publication Acceptance Date: July 11, 2009
Publication Date: July 11, 2009
Citation: Fadly, A.M., Kim, T., Mays, J.K., Silva, R.F. 2009. Pathogenicity of a Molecular Clone of Marek's Disease Virus with an Insert of Long Terminal Repeat of Reticuloendotheliosis Virus [abstract]. In: American Veterinary Medical Association Convention Notes, July 11-14, 2009, Seattle, Washington. Paper No. 7661.

Technical Abstract: Recently, we have inserted reticuloendotheliosis virus (REV) long terminal repeat (LTR) sequences into strain Md5 of Marek’s disease (MD) virus (MDV) using rMd5 bacterial artificial chromosome (BAC). The rMd5 BAC with REV LTR insert was passed in duck-embryo fibroblast for 40 passages. Chickens of ADOL line 15 X 7 with and without MD maternal antibodies were used to study the pathogenicity of rMd5 BAC with REV LTR insert, and to compare it with that of rMd5 BAC without REV LTR insert. The influence of REV LTR inserts on the pathogenicity of rMd5 will be discussed.