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United States Department of Agriculture

Agricultural Research Service

Research Project: MOLECULAR SYSTEMATICS AND COMPARATIVE POPULATION GENETICS OF PARASITIC ORGANISMS THAT THREATEN FOOD SAFETY AND SECURITY Title: The Origin of Malignant Malaria

Authors
item Rich, Stephen - UNIV OF MA, AMHERST
item Leendertz, Fabian - ROBERT KOCH INST, GERMANY
item Xu, Guang - UNIV OF MA, AMHERST
item Lebreton, Matthew - GVFI, SAN FRANCISCO, CA
item Djoko, Cyrille - GVFI, AND CAMEROON
item Aminake, Makoah - UNIV OF YAOUNDE, CAMEROON
item Takang, Eric - UNIV OF MA, AMHERST
item Diffo, Joseph - UNIV OF YAOUNDE, CAMEROON
item Pike, Brian - GVFI, SAN FRANCISCO, CA
item Rosenthal, Benjamin
item Formenty, Pierre - WHO, COTE D'IVOIRE
item Boesch, Christophe - MPIDA, LEIPZIG GERMANY
item Ayala, Francisco - UNIV OF CA, IRVINE
item Wolfe, Nathan - STANFORD UNIV, CA

Submitted to: Proceedings of the National Academy of Sciences
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: July 13, 2009
Publication Date: September 1, 2009
Citation: Rich, S.M., Leendertz, F.H., Xu, G., Lebreton, M., Djoko, C.F., Aminake, M.N., Takang, E.E., Diffo, J.L., Pike, B., Rosenthal, B.M., Formenty, P., Boesch, C., Ayala, F., Wolfe, N. 2009. The Origin of Malignant Malaria. Proceedings of the National Academy of Sciences. 106(35):14902-14907.

Interpretive Summary: Several parasite species cause malaria in human beings, but one is principally responsible for severe disease and death: Plasmodium falciparum. The evolutionary origins of this parasite are enigmatic, in spite of its dubious distinction as the leading infectious cause of human mortality. The idea that this parasite might have been acquired by human beings from birds was abandoned when it was realized that a closely related species of parasites occurs in our closest living relatives, the chimpanzees. Since then, many prominent studies have assumed that these malaria parasites co-speciated with their human and chimpanzee hosts, implying several million years of independent evolution. Here, we overturn this concept using new data (from parasites in chimpanzees) and demonstrate that P. falciparm diverged, only very recently, from ancestors harbored by chimpanzees. Like many other infections, the agent of human malaria had a zoonotic origin.

Technical Abstract: Plasmodium falciparum is the causative agent of malignant malaria, which is among the most severe human infectious diseases. Despite its overwhelming significance to human health, the parasite’s origins remain unclear. The favored origin hypothesis holds that P. falciparum and its closest known relative, the chimpanzee parasite, P. reichenowi, descended from distinct ancestors in their respective human and chimpanzee hosts 2. Here, we describe extensive diversity among several new isolates of P. reichenowi and demonstrate that their common ancestor also gave rise to P. falciparum. Evidently, the agent of malignant malaria was transferred once, to humans, from chimpanzees.

Last Modified: 11/28/2014
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