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United States Department of Agriculture

Agricultural Research Service

Title: Increased Expression of Receptors for Orexigenic Factors in Nodose Ganglion of Diet-Induced Obese Rats

Authors
item Paulino, Gabriel - UCD, VET.MED., ANATOMY
item Barbier DE La Serre, Claire - UCD, VET.MED., ANATOMY
item Knotts, Trina
item Oort, Pieter
item Newman, John
item Adams, Sean
item Raybould, Helen - UCD, VET.MED., ANATOMY

Submitted to: American Journal of Physiology - Endocrinology and Metabolism
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: January 30, 2009
Publication Date: February 3, 2009
Repository URL: http://ajpendo.physiology.org/cgi/reprint/90796.2008v1
Citation: Paulino, G., Barbier De La Serre, C., Knotts, T.A., Oort, P.J., Newman, J.W., Adams, S.H., Raybould, H. 2009. INCREASED EXPRESSION OF RECEPTORS FOR OREXIGENIC FACTORS IN NODOSE GANGLION OF DIET-INDUCED OBESE RATS. American Journal of Physiology - Endocrinology and Metabolism, 296:898-903.

Interpretive Summary: The vagal afferent pathway is important in short-term regulation of food intake and decreased activation of this neural pathway with long-term ingestion of a high fat diet may contribute to hyperphagic weight gain. We test the hypothesis that expression of genes encoding receptors for orexigenic factors in vagal afferent neurons are increased by long-term ingestion of a high fat diet, thus supporting orexigenic signals from the gut. Obesity prone (DIO P) rats fed a high fat diet showed increased body weight and hyperleptinemia compared to low fat fed controls and high fat fed diet-induced obese resistant (DIO R) rats. Expression of the type I cannabinoid receptor and growth hormone secretagogue receptor in the nodose ganglia was increased in DIO P compared with low fat fed or DIO-R rats. Shifts in the balance between orexigenic and anorexigenic signals within the vagal afferent pathway may influence food intake and body weight gain induced by high fat diets.

Technical Abstract: The vagal afferent pathway is important in short-term regulation of food intake and decreased activation of this neural pathway with long-term ingestion of a high fat diet may contribute to hyperphagic weight gain. We test the hypothesis that expression of genes encoding receptors for orexigenic factors in vagal afferent neurons are increased by long-term ingestion of a high fat diet, thus supporting orexigenic signals from the gut. Obesity prone (DIO P) rats fed a high fat diet showed increased body weight and hyperleptinemia compared to low fat fed controls and high fat fed diet-induced obese resistant (DIO R) rats. Expression of the type I cannabinoid receptor and growth hormone secretagogue receptor in the nodose ganglia was increased in DIO P compared with low fat fed or DIO-R rats. Shifts in the balance between orexigenic and anorexigenic signals within the vagal afferent pathway may influence food intake and body weight gain induced by high fat diets.

Last Modified: 4/16/2014