Submitted to: American Chemical Society Symposium Series
Publication Type: Book / Chapter
Publication Acceptance Date: May 8, 2009
Publication Date: December 20, 2009
Citation: Appell, M.D., Maragos, C.M. 2009. A Closer Look at Cyclodextrins in Mycotoxin Analysis. In: Appell, M., Kendra, D.F., Trucksess, M.W., editors. American Chemical Society Symposium Series 1031, Mycotoxin Prevention and Control in Agriculture. Washington D.C.: American Chemical Society. p. 293-305. Technical Abstract: Cyclodextrins are a class of cyclic oligosaccharides with a variety of applications, including use as recognition components for low molecular weight molecules in methods of detection. These cyclomaltoses are of special interest in mycotoxin analysis for enhancing spectroscopic properties of several mycotoxins under aqueous conditions, including aflatoxins, zearalenone, ochratoxin A, and through chemical derivatization, T-2 toxin. Applications of cyclodextrins are frequently associated with inclusion complex formation. Fluorescence spectroscopic studies determined zearalenone and ß-cyclodextrin form a 1:1 complex. Theoretical studies of structural aspects and energies associated with complex stabilization suggest cyclodextrin-mycotoxin interactions are influenced by the size of the mycotoxin and favorable changes in enthalpy associated with complex formation. The results provide a better understanding of the effectiveness and limitations of incorporating cyclodextrins into mycotoxin analysis.