Location: Genetics, Breeding, & Animal Health
Title: A putative quantitative trait locus on chromosome 20 associated with bovine pathogenic disease incidence Authors
Submitted to: Animal Genetics International Conference Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: May 20, 2008
Publication Date: July 20, 2008
Citation: Casas, E., Snowder, G.D. 2008. A putative quantitative trait locus on chromosome 20 associated with bovine pathogenic disease incidence [Abstract]. XXXI Animal Genetics International Conference Proceedings, July 20-24, 2008, Amsterdam, The Netherlands. Poster #2017. Technical Abstract: The objective was to detect QTL associated with the incidence of multiple pathogenic diseases in offspring from half-sib bovine families. Four F1 sires were used to produce offspring: Brahman x Hereford (BH; n = 547), Piedmontese x Angus (PA; n = 209), Brahman x Angus (BA; n = 176), and Belgian Blue x MARC III (BM; n = 246). Treatment records for bovine respiratory disease, infectious keratoconjunctivitis (pinkeye), and infectious pododermatitis (footrot) were available for all the offspring from birth to slaughter. The incidences of these three microbial pathogenic diseases were combined into a single binary trait to represent an overall pathogenic disease incidence. Offspring diagnosed and treated for one or more of the previously mentioned pathogenic diseases were coded as a 1 for affected. Cattle with no treatment record were coded as 0 for healthy. A putative QTL for pathogenic disease incidence was detected in the family derived from the BH sire at the genome-wise suggestive level. This was supported by evidence, in the same chromosomal region, of a similar QTL on the family derived from the PA sire. The maximum F-statistic (F = 13.52; P = 0.0003) was located at centimorgan 18. The support interval of the QTL spanned from centimorgan 9 to centimorgan 28. Further studies should explore this QTL using other bovine populations to further confirm the QTL and refine the QTL support interval. Offspring inheriting the Hereford allele, in the family from the BH sire, and the Angus allele, in the family from the PA sire, were less susceptible to incidence of pathogenic diseases, when compared to those inheriting the Brahman allele and Piedmontese allele, from the BH and PA sires, respectively.