ARS | Publication request: Botryolides A-E, Decarestrictine Analogues from a Fungicolous Botryotrichum sp. (NRRL 38180)

Submitted to: Journal of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: November 5, 2007
Publication Date: December 30, 2007
Citation: Sy, A.A., Swenson, D.C., Gloer, J.B., Wicklow, D.T. 2007. Botryolides A-E, Decarestrictine Analogues from a Fungicolous Botryotrichum sp. (NRRL 38180). Journal of Natural Products. 71(3):415-419.

Interpretive Summary: Fungi that parasitize and kill other fungi offer a potential source of novel antifungal agents useful to agriculture and medicine. The Botryotrichum state of Chaetomium piluliferum NRRL 38180, encountered as a colonist of a wood decay fungus growing on a dead hardwood branch, collected in Florida, was examined for its ability to produce antifungal agents and other bioactive metabolites. Botryolides A-D are reported as new fungal metabolites which did not show antimicrobial activity in our assays but are closely related to decarestrictines, a class of metabolites found to have a wide range of bioactivites.

Technical Abstract: Four new decarestrictine analogs (botryolides A–D; 1–4), a biosynthetically related gamma-lactone (botryolide E; 5), and the known compounds decarestrictine D(6) and sterigmatocystin have been isolated from cultures of a fungicolous isolate of Botryotrichum sp. (NRRL 38180). The structures of these compounds were determined by analysis of 2D NMR and ESIMS data. The relative configurations of 1–5 were established on the basis of NMR data and/or X-ray diffraction analysis, while the absolute configuration of 1 was assigned using the modified Mosher method.