Submitted to: Agricultural Experiment Station Publication
Publication Type: Experiment Station
Publication Acceptance Date: December 1, 2007
Publication Date: January 2, 2007
Citation: Lunney, J.K. 2007. BARC 2007 experiment station report for NC-229 national project on porcine reproductive and respiratory syndrome (PRRS): Mechanism of disease and methods for the detection, protection and elimintation of the PRRS virus.Agricultural Experiment Station Publication. Technical Abstract: The NC-229 national project “Porcine Reproductive and Respiratory Syndrome (PRRS): Methods for the integrated control, prevention, and elimination of PRRS in United States swine herds.” This station report summarizes the BARC lab’s recent research progress. Four major projects have been addressed. 1) Based on a study of 400 pigs by U Nebraska and ARS BARC scientists serum levels of the innate cytokine interleukin-8 (IL-8) and the anti-viral protein interferon-gamma (IFNg) have been found to be correlated with the ability of certain pigs to resist PRRS virus infection. These data establish targets for future studies (the PRRS host genomics consortium) to determine if specific immune gene alleles are associated with PRRS virus resistance; 2) Work with SD State scientists on a North American Type 1 PRRSV infectious clone stimulation of immune responses have proven to be as effective as the parental type I PRRS virus; 3) Work with UMN and SD State scientists on short term PRRSV infections of boars have affirmed the reproductive tissues that harbor the virus and illustrated the cytokines in seminal plasma; and 4) Work with samples collected at Iowa State Univ. for the “Big Pig” project have highlighted the potential role of immune proteins, IL8 and IFNg, in determining which pigs will prevent PRRS virus from becoming persistent. Overall this information will help producers to decrease breeding of PRRSV susceptible pigs, and potentially select for PRRSV resistant stock.