Page Banner

United States Department of Agriculture

Agricultural Research Service

Research Project: NEWCASTLE DISEASE EPIDEMIOLOGY, PATHOGENESIS, AND CONTROL

Location: Exotic and Emerging Avian Viral Diseases Research Unit

Title: The role of antigenic composition of Newcastle disease (ND) vaccines in ND control

Authors
item MILLER, PATTI
item Estevez, Carlos
item YU, QINGZHONG
item SUAREZ, DAVID
item King, Daniel

Submitted to: American Association of Avian Pathologists
Publication Type: Abstract Only
Publication Acceptance Date: April 27, 2008
Publication Date: July 19, 2008
Citation: Miller, P.J., Estevez, C., Yu, Q., Suarez, D.L., King, D.J. 2008. The role of antigenic composition of Newcastle disease (ND) vaccines in ND control [abstract]. In: Proceedings of the American Association of Avian Pathologists annual meeting, July 19-23, 2008, New Orleans, Louisiana. p. 65.

Technical Abstract: Virulent Newcastle disease virus (NDV) isolates from recent outbreaks are the same serotype but are antigenically different from current vaccine strains. Recent experiments in chickens with an inactivated vaccine show significantly less virus shed in birds vaccinated with homologous vaccines compared to chickens vaccinated with heterologous vaccines. Subsequent experiments have compared the protection induced in chickens by live vaccines formulated from B1, LaSota, Ulster, and recombinant viruses that express the hemagglutinin (HN) gene or the HN and fusion (F) genes of CA 2002. Vaccinates were challenged with virulent CA 2002 (genotype V) or Texas GB, a virus of the same genotype (II) as LaSota vaccines. Results are similar to killed vaccines with reduced shed when birds are vaccinated with homologous vaccines.

Last Modified: 9/10/2014