Technical Abstract: Three sets of corn germplasm (including both inbred lines and experimental hybrids from diverse genetic background) have been examined separately for major ear-feeding insect and ear-colonizing disease resistance for two years. The ear-feeding insect damage assessment included corn earworm, maize weevil, and stink bug damage, whereas common smut infection was the only plant pathogen that was included in this study. Multiple insect and smut-resistant corn germplasm was identified. The correlation of insect damage to maize phenotypic traits was also assessed. Ramifications of multiple ear-colonizing pest resistance and possible biochemical and physiological bases for multiple pest resistance will also be discussed.