ARS | Publication request: Gene expression responses to highly pathogenic avian influenza H5N1 virus infections in ducks

Submitted to: American Association of Avian Pathologists
Publication Type: Abstract Only
Publication Acceptance Date: January 15, 2008
Publication Date: July 20, 2008
Citation: Pantin Jackwood, M.J., Kapczynski, D.R., Wasilenko, J.L., Sarmento, L., Afonso, C.L. 2008. Gene expression responses to highly pathogenic avian influenza H5N1 virus infections in ducks [abstract]. 145th American Medical Association Annual Meeting, July 20-23, 2008, New Orleans, Louisiana. 2008 CDROM.

Technical Abstract: Differences in host response to infection with avian influenza (AI) viruses were investigated by identifying genes differentially expressed in tissues of infected ducks. Clear differences in pathogenicity were observed among ducks inoculated with five H5N1 HPAI viruses. Virus titers in tissues correlated with severity of the disease. A complete chicken genome microarray was used to determine differences in gene expression in the spleen in response to infection with the AI viruses. Semi-quantitative RT-PCR was also performed on selected genes related to host response. The results provide important information on different mechanisms potentially induced by avian influenza viruses to modulate innate immune host response of the ducks.