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United States Department of Agriculture

Agricultural Research Service

Research Project: IDENTIFICATION AND CHARACTERIZATION OF GENES AFFECTING COOL AND COLD WATER AQUACULTURE PRODUCTION

Location: Cool and Cold Water Aquaculture Research

Title: Associations of Markers Linked to Major Histocompatibility (MH) Regions With Disease Resistance in Rainbow Trout

Authors
item Palti, Yniv
item Johnson, Nathan
item Rexroad, Caird
item Welch, Timothy
item Wiens, Gregory
item Silverstein, Jeff
item Vallejo, Roger

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: March 30, 2007
Publication Date: May 2, 2007
Citation: Palti, Y., Johnson, N., Rexroad III, C.E., Welch, T.J., Wiens, G.D., Silverstein, J., Vallejo, R.L. Associations of Markers Linked to Major Histocompatibility (MH) Regions With Disease Resistance in Rainbow Trout. Meeting Abstract.

Technical Abstract: The 2005 NCCCWA brood year (75 full-sib families) were challenged with Flavobacterium psychrophilum, the causative agent of bacterial coldwater disease and rainbow trout fry syndrome. Overall mortality rate was 70% with large variation among families. Resistance to the disease was assessed by monitoring post challenge days to death. Phenotypic variation and additive genetic variation were estimated using mixed models of survival analysis. Microsatellite markers were previously isolated from BAC clones that harbor genes of interest and mapped on to the rainbow trout genetic linkage map. The parents and grandparents of the 2005 brood year families were genotyped with markers linked to the four major histocompatibility (MH) genomic regions to assess linkage disequilibrium (LD) between those genomic regions and resistance to the bacterial disease. The impact of MH sequence variation on selective breeding for disease resistance in aquaculture is discussed.

Last Modified: 8/27/2014
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