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United States Department of Agriculture

Agricultural Research Service

Research Project: DIOXINS AND OTHER ENVIRONMENTAL CONTAMINANTS IN FOOD

Location: Animal Metabolism-Agricultural Chemicals Research

Title: Introduction, recent advances in immunochemistry and their application to agrochemicals.

Authors
item Van Emon, Jeanette - US-EPA
item Shelver, Weilin

Submitted to: Journal of Agricultural and Food Chemistry
Publication Type: Review Article
Publication Acceptance Date: March 14, 2007
Publication Date: April 25, 2007
Citation: Van Emon, J.M., Shelver, W.L. 2007. Journal of Agricultural and Food Chemistry 55:3749-3749.

Interpretive Summary: This publication summarizes the presentations at a symposium on "Recent Advancements in Immunochemistry and Their Application to Agrochemicals" at the 232nd meeting of the American Chemical Society in San Francisco (September 10-14, 2006) and will appear as the introduction in a special segment of the Journal of Agricultural and Food Chemistry. The challenge of accurately measuring extremely small amounts of specific components in complex samples such as meat or soil is daunting with the first attempts as recently as 25 years ago. Progress has been extremely rapid, and this meeting gathered scientists together from all over the world to share their experience.

Technical Abstract: The cluster of papers presented here, represent a cross section of the topics discussed at the Agrochemicals Division Symposium on Recent Advancements in Immunochemistry and Their Application to Agrochemicals, held at the 232nd meeting of the American Chemical Society in San Francisco, CA (September 10-14, 2006). The symposium showcased the application of immunochemical analysis to a wide variety of analytes in diverse matrices as well as new automation capabilities, novel detection techniques for bioanalytical methods, and the coupling of immunoextraction techniques with instrumental detection. Participants from Asia, Europe and North America provided an international backdrop to the symposium and illustrated the worldwide application of immunochemical analysis. The challenge of achieving ever-lower detection limits in complex matrices necessitates innovation in every aspect of the analysis. Additional complications arise when multiple analytes must be determined in a single sample. These issues have been reviewed to assess technological advances that are beneficial to analysts from diverse disciplines. The papers included here discuss advances in immunoassay detection for the analysis of urinary biomarkers, the simultaneous detection of different proteins for food analysis, and the application of nanotechnology to agricultural and food chemistry. A hybrid method of flow-through immunoassay and liquid chromatography for Ochratoxin A is presented in determining the quality of wine. An efficient immunoconcentration method for natural products such traditional Chinese medicine is also described. The on-line coupling of immunoextraction separation and cleanup techniques with instrumental detection are presented, and detailed information for method development is provided. Together, these papers provide insight into the advances in immunochemical methods for residue analysis.

Last Modified: 4/16/2014
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