Technical Abstract: Tuberculosis due to infection with Mycobacterium bovis is a problem in both captive and free-ranging Cervidae in the United States. Captive Cervidae are included in the United States Department of Agriculture Bovine Eradication Campaign and as such are subject to rules and regulations regarding testing for tuberculosis. The most commonly used test, intradermal skin testing, involves repeated handling of animals and is not highly specific. Research is being conducted on blood-based assays that would decrease animal handling and improve specificity.