Submitted to: American Association of Avian Pathologist
Publication Type: Abstract Only
Publication Acceptance Date: January 5, 2007
Publication Date: July 14, 2007
Citation: Sarmento, L., Zaffuto, K.M., Pantin Jackwood, M.J., Afonso, C.L. 2007. Differential growth of avian influenza virus in chicken and duck cells [abstract]. 144th American Veterinary Medical Association Annual Meeting, July 14-19, 2007, Washington, DC. CD-ROM. Technical Abstract: Ducks and chickens infected with AI viruses display clear differences in disease manifestation. To understand the mechanisms responsible for these differences we have determined the ability of several AI isolates to replicate in primary tracheal epithelial cells and fibroblasts from both species. Results suggest differences in the capacity of the host species to support viral replication, and a varied ability of different avian influenza viruses to infect identical cell types. Transcriptional host responses were analyzed using a microarray of the complete chicken genome.