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United States Department of Agriculture

Agricultural Research Service

Title: Efficacy of three inactivated vaccines against challenge with HPAI H5N1 Vietnam/05 viruses in ducks

Authors
item Pantin-Jackwood, Mary
item Suarez, David
item Pfeiffer, Jennifer
item Sarmento, Luciana

Submitted to: American Association of Avian Pathologist
Publication Type: Abstract Only
Publication Acceptance Date: January 26, 2007
Publication Date: July 14, 2007
Citation: Pantin Jackwood, M.J., Suarez, D.L., Pfeiffer, J., Sarmento, L. 2007. Efficacy of three inactivated vaccines against challenge with HPAI H5N1 Vietnam/05 viruses in ducks [abstract]. 144th American Veterinary medical Association Annual Meeting, July 14-19, 2007, Washington, DC. CD-ROM.

Technical Abstract: The objective of the study was to compare the efficacy of inactivated vaccines containing a European isolate (A/turkey/England/73, H5N2 Chinese commercial vaccine), an American isolate (A/chicken/Hidalgo/94, H5N2 Mexican commercial vaccine), or a recombinant virus (RE-1, H5N1 recombinant Chinese vaccine) in protecting ducks against a HPAI H5N1 challenge. One week-old Pekin ducks were vaccinated and challenged two weeks later with a lethal dose of either A/duck/Vietnam/218/05 or A/duck/Vietnam/203/05. All unvaccinated ducks died within 5 days, whereas 95% of ducks vaccinated with A/turkey/England/73 and 100% of ducks vaccinated with either A/chicken/Hidalgo/94 or RE-1 were protected. However, oral virus shedding was detected in 10 to 12 out of 20 ducks from each group of vaccinated birds.

Last Modified: 4/16/2014