Technical Abstract: A collaborative study was conducted to determine multiple pesticide residues in fruits and vegetables using a quick, simple, inexpensive, and effective sample preparation method followed by concurrent analysis with gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). For short, the method is known as QuEChERS (pronounced "catchers"), which stands for quick, easy, cheap, effective, rugged, and safe. Twenty representative pesticides were fortified in 3 matrices (grapes, lettuces, and oranges) at 3 duplicate levels unknown to the collaborators ranging from 10 to 1,000 ng/g. Additionally, 8 incurred pesticide residues were determined. Thirteen labs from 7 countries provided results in the study, and a variety of different instruments were used by collaborators. To achieve <10 ng/g detection limits in modern GC-MS, large volume injection (LVI) of 8 'L is typically needed, or the final extract can be concentrated and solvent exchanged to toluene (4 g/mL) in which case 2 'L splitless injection is used. In the study, the averaged results for data from 7-13 labs (not using internal standardization) for the 18 blind duplicates at the 9 spiking levels in the 3 matrices showed 87% recovery and 21% RSD inter-lab precision. Intra-lab repeatabilities for the method averaged 9.8% RSD for all analytes. The collaborative study results demonstrate that the QuEChERS method is fit-for-purpose to monitor many pesticide residues in fruits and vegetables, and the Study Director recommends that it be adopted official first action.