Page Banner

United States Department of Agriculture

Agricultural Research Service

Research Project: DISCOVERY AND DEVELOPMENT OF NATURAL PRODUCTS FOR PHARMACEUTICAL AND AGRICHEMICAL APPLICATIONS Title: Biological Stress Response Terminology: Integrating the Concepts of Adaptive Response and Preconditioning Stress Within a Hormetic Dose-Response Framework

Authors
item Calabrese, Edward - UNIV. OF MASSACHUSETTS
item Bailer, A. John - MIAMI UNIVERSITY
item Bachmann, Kenneth - UNIVERSITY OF TOLEDO
item Bolger, P. Michael - U.S. FOOD & DRUG ADMIN.
item Borak, Jonathan - YALE UNIVERSITY
item Cai, Lu - UNIV. OF LOUISVILLE-MED.
item Cedergreen, Nina - ROYAL VET&AG UNIV-DENMARK
item Chiueh, Chuang - TAIPEI MED. UNIV.-TAIWAN
item Cherian, M. George - UNIV. OF WESTERN ONTARIO
item Clarkson, Thomas - UNIV. OF ROCHESTER
item Cook, Ralph - RRC CONSULTING, LLC
item Diamond, David - UNIV. OF SOUTH FLORIDA
item Doolittle, David - RJR TOBACCO COMPANY
item Dorato, Michael - ELI LILLY & COMPANY
item Duke, Stephen
item Feinendegen, Ludwig - HEINRICH-HEINE-UNIV-GRMNY
item Gardner, Donald - INHALATION TOXICOL. ASSOC
item Hart, Ronald - US FOOD & DRUG ADMIN.
item Hastings, Kenneth - U.S. FOOD & DRUG ADMIN
item Hayes, A - HARVARD UNIVERSITY
item Hoffman, George - COLLEGE OF HOLY CROSS
item Jaworowski, Zbigniew - CENTRAL LAB FOR RAD PROT
item Johnson, Thomas - UNIV. OF COLORADO
item Keller, John - PROFESSIONAL CONSULT. SVC
item Klaunig, James - INDIANA UNIV.-MED. SCHOOL
item Knudsen, Thomas - UNIV. OF LOUISVILLE
item Kozumbo, Walter - AIR FORCE-OFFICE-SCI.RES.
item Lettieri, Teresa - EUROPEAN COMM.-JOINT RES.
item Liu, Shu-Zheng - NORMAN BETHUNE UNIV. MED.
item Maisseu, Andre - WORLD CNCL-NUCLEAR WORKER
item Maynard, Kenneth - SANOFI-AVENTIS U.S. INC.
item Masoro, Edward - TEXAS TECH UNIV.-RETIRED
item Mothersil, Carmel - MCMASTER UNIVERSITY
item Newlin, David - RTI INTERNATIONAL
item Oehme, Frederick - KANSAS STATE UNIV.
item Phalen, Robert - UNIV. OF CA - IRVINE
item Philbert, Martin - UNIV. OF MI-PUBLIC HLTH.
item Rattan, Suresh I.S. - UNIV. OF AAHUS-DENMARK
item Riviere, Jim - NORTH CAROLINA STATE UNIV
item Rodricks, Joseph - ENVIRON INT. CORP.
item Sapolsky, Robert - STANFORD UNIV-MED SCHOOL
item Scott, Bobby - LOVELACE RESP. RES. INST.
item Seymour, Colin - MCMASTER UNIVERSITY
item Smith-Sonneborn, Joan - UNIV. OF WYOMING
item Snow, Elizabeth - DEAKIN UNIV.-AUSTRALIA
item Spear, Linda - BINGHAMPTON UNIV.
item Stevenson, Donald - DERMIGEN CONSULTING GRP.
item Thomas, Yolene - INSTITUT ANDRE LWOFF-FRNC
item Williams, Gary - NEW YORK MEDICAL COLLEGE
item Mattson, Mark - NATIONAL INST. ON AGING

Submitted to: Journal of Toxicology and Applied Pharmacology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: February 26, 2007
Publication Date: March 7, 2007
Citation: Calabrese, E.J., Bailer, A., Bachmann, K.A., Bolger, P., Borak, J., Cai, L., Cedergreen, N., Chiueh, C.C., Cherian, M., Clarkson, T.W., Cook, R.R., Diamond, D.M., Doolittle, D.J., Dorato, M.A., Duke, S.O., Feinendegen, L., Gardner, D.E., Hart, R.W., Hastings, K.L., Hayes, A.W., Hoffman, G.R., Jaworowski, Z., Johnson, T.E., Keller, J.G., Klaunig, J.E., Knudsen, T.B., Kozumbo, W.J., Lettieri, T., Liu, S., Maisseu, A., Maynard, K., Masoro, E.J., Mothersil, C., Newlin, D.B., Oehme, F.W., Phalen, R.F., Philbert, M.A., Rattan, S., Riviere, J.E., Rodricks, J., Sapolsky, R.M., Scott, B.R., Seymour, C., Smith-Sonneborn, J., Snow, E.T., Spear, L., Stevenson, D.E., Thomas, Y., Williams, G.M., Mattson, M.P. 2007. Biological Stress Response Terminology: Integrating the Concepts of Adaptive Response and Preconditioning Stress Within a Hormetic Dose-Response Framework. Journal of Toxicology and Applied Pharmacology. 222:122-128.

Interpretive Summary: Hormesis is the stimulatory effect of a subtoxic level of a toxin. Terminology regarding this and related phenomena is not uniform, causing confusion. This paper, with authors from all areas of medicine, bioscience, and toxicology, provides a uniform terminology for hormesis and related phenomena.

Technical Abstract: Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose-response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose- response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.

Last Modified: 10/22/2014