Author
CALABRESE, EDWARD - UNIV. OF MASSACHUSETTS | |
BAILER, A. JOHN - MIAMI UNIVERSITY | |
BACHMANN, KENNETH - UNIVERSITY OF TOLEDO | |
BOLGER, P. MICHAEL - U.S. FOOD & DRUG ADMIN. | |
BORAK, JONATHAN - YALE UNIVERSITY | |
CAI, LU - UNIV. OF LOUISVILLE-MED. | |
CEDERGREEN, NINA - ROYAL VET&AG UNIV-DENMARK | |
CHIUEH, CHUANG - TAIPEI MED. UNIV.-TAIWAN | |
CHERIAN, M. GEORGE - UNIV. OF WESTERN ONTARIO | |
CLARKSON, THOMAS - UNIV. OF ROCHESTER | |
COOK, RALPH - RRC CONSULTING, LLC | |
DIAMOND, DAVID - UNIV. OF SOUTH FLORIDA | |
DOOLITTLE, DAVID - RJR TOBACCO COMPANY | |
DORATO, MICHAEL - ELI LILLY & COMPANY | |
Duke, Stephen | |
FEINENDEGEN, LUDWIG - HEINRICH-HEINE-UNIV-GRMNY | |
GARDNER, DONALD - INHALATION TOXICOL. ASSOC | |
HART, RONALD - US FOOD & DRUG ADMIN. | |
HASTINGS, KENNETH - U.S. FOOD & DRUG ADMIN | |
HAYES, A - HARVARD UNIVERSITY | |
HOFFMAN, GEORGE - COLLEGE OF HOLY CROSS | |
JAWOROWSKI, ZBIGNIEW - CENTRAL LAB FOR RAD PROT | |
JOHNSON, THOMAS - UNIV. OF COLORADO | |
KELLER, JOHN - PROFESSIONAL CONSULT. SVC | |
KLAUNIG, JAMES - INDIANA UNIV.-MED. SCHOOL | |
KNUDSEN, THOMAS - UNIV. OF LOUISVILLE | |
KOZUMBO, WALTER - AIR FORCE-OFFICE-SCI.RES. | |
LETTIERI, TERESA - EUROPEAN COMM.-JOINT RES. | |
LIU, SHU-ZHENG - NORMAN BETHUNE UNIV. MED. | |
MAISSEU, ANDRE - WORLD CNCL-NUCLEAR WORKER | |
MAYNARD, KENNETH - SANOFI-AVENTIS U.S. INC. | |
MASORO, EDWARD - TEXAS TECH UNIV.-RETIRED | |
MOTHERSIL, CARMEL - MCMASTER UNIVERSITY | |
NEWLIN, DAVID - RTI INTERNATIONAL | |
OEHME, FREDERICK - KANSAS STATE UNIV. | |
PHALEN, ROBERT - UNIV. OF CA - IRVINE | |
PHILBERT, MARTIN - UNIV. OF MI-PUBLIC HLTH. | |
RATTAN, SURESH I.S. - UNIV. OF AAHUS-DENMARK | |
RIVIERE, JIM - NORTH CAROLINA STATE UNIV | |
RODRICKS, JOSEPH - ENVIRON INT. CORP. | |
SAPOLSKY, ROBERT - STANFORD UNIV-MED SCHOOL | |
SCOTT, BOBBY - LOVELACE RESP. RES. INST. | |
SEYMOUR, COLIN - MCMASTER UNIVERSITY | |
SMITH-SONNEBORN, JOAN - UNIV. OF WYOMING | |
SNOW, ELIZABETH - DEAKIN UNIV.-AUSTRALIA | |
SPEAR, LINDA - BINGHAMPTON UNIV. | |
STEVENSON, DONALD - DERMIGEN CONSULTING GRP. | |
THOMAS, YOLENE - INSTITUT ANDRE LWOFF-FRNC | |
WILLIAMS, GARY - NEW YORK MEDICAL COLLEGE | |
MATTSON, MARK - NATIONAL INST. ON AGING |
Submitted to: Journal of Toxicology and Applied Pharmacology
Publication Type: Peer Reviewed Journal Publication Acceptance Date: 2/26/2007 Publication Date: 3/7/2007 Citation: Calabrese, E.J., Bailer, A., Bachmann, K.A., Bolger, P., Borak, J., Cai, L., Cedergreen, N., Chiueh, C.C., Cherian, M., Clarkson, T.W., Cook, R.R., Diamond, D.M., Doolittle, D.J., Dorato, M.A., Duke, S.O., Feinendegen, L., Gardner, D.E., Hart, R.W., Hastings, K.L., Hayes, A.W., Hoffman, G.R., Jaworowski, Z., Johnson, T.E., Keller, J.G., Klaunig, J.E., Knudsen, T.B., Kozumbo, W.J., Lettieri, T., Liu, S., Maisseu, A., Maynard, K., Masoro, E.J., Mothersil, C., Newlin, D.B., Oehme, F.W., Phalen, R.F., Philbert, M.A., Rattan, S., Riviere, J.E., Rodricks, J., Sapolsky, R.M., Scott, B.R., Seymour, C., Smith-Sonneborn, J., Snow, E.T., Spear, L., Stevenson, D.E., Thomas, Y., Williams, G.M., Mattson, M.P. 2007. Biological Stress Response Terminology: Integrating the Concepts of Adaptive Response and Preconditioning Stress Within a Hormetic Dose-Response Framework. Journal of Toxicology and Applied Pharmacology. 222:122-128. Interpretive Summary: Hormesis is the stimulatory effect of a subtoxic level of a toxin. Terminology regarding this and related phenomena is not uniform, causing confusion. This paper, with authors from all areas of medicine, bioscience, and toxicology, provides a uniform terminology for hormesis and related phenomena. Technical Abstract: Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose-response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose- response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines. |