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United States Department of Agriculture

Agricultural Research Service

Title: Experimental Study on Preparation of Microparticles Using Supercritical Co2 Spray Drying

Authors
item Li, Baoguo - UNIV. OF SHANGHAI, CHINA
item Yaqing, Wu - UNIV. OF SHANGHAI, CHINA
item Pan, Zhongli

Submitted to: Proceedings of the American Society of Agricultural and Biological Engineers International (ASABE)
Publication Type: Proceedings
Publication Acceptance Date: May 12, 2006
Publication Date: July 9, 2006
Repository URL: http://www.asabe.org
Citation: Baoguo Li, Wu Yaqing, Zhongli Pan, Z. 2006. Experimental study on preparation of microparticles using supercritical co2 spray drying. Proceedings of the American Society of Agricultural and Biological Engineers International (ASABE). Paper No. 066204:1-16. St. Joseph, Mich.:ASABE

Interpretive Summary: Supercritical CO2 spray drying has been considered as an advanced technique for producing microparticles. This research studied the effect of drying conditions and design parameters on the particle sizes of biomaterials dried with supercritical CO2 spray drying.

Technical Abstract: Even though common spray drying has been widely used for drying food and related products, the effect of drying conditions of supercritical CO2 spray drying on the particle sizes of dried products has not been well studied. The objective of this study was to study the effect of drying conditions and design parameters on the particle sizes of biomaterials dried with supercritical CO2 spray drying. The ethyl cellulose (EC) microparticles were prepared with supercritical CO2 as the dry medium using an experimental spray drying apparatus. This research studied the influences of spray nozzle diameter, mass ratio of gas to liquid, solution concentration, temperature and pressure on the physical characteristics of ethyl cellulose microparticles. The results indicated that the average size of the dried particles ranged from 1.07 to 9.84 µm. The spray nozzle with 8 mm diameter produced smaller microparticles with narrower distribution than the 4mm spray nozzle. The average particle size increased with the increase of the ratio of gas to liquid. Also, the average size and distribution of the microparticles increased with the rise of temperature and solution concentration, but decreased with the increase of pressure.

Last Modified: 12/18/2014