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United States Department of Agriculture

Agricultural Research Service

Title: Phytophthora Genome Sequences Uncover Evolutionary Origins and Mechanisms of Pathogenesis

Authors
item Tyler, Brett - VIRGINIA POLYTECHNIC INST
item Tripathy, Sucheta - VIRGINIA POLYTECHNIC INST
item Zhang, Xuemin - VIRGINIA POLYTECHNIC INST
item Dehal, Paramvir - DOE JOINT GENOME INST
item Jiang, Rays - VIRGINIA POLYTECHNIC INST
item Aerts, Andrea - DOE JOINT GENOME INST
item Arredondo, Felipe - VIRGINIA POLYTECHNIC INST
item Baxter, Laura - HORTICULTURE RESEARCH INT
item Bensasson, Douda - DOE JOINT GENOME INST
item Beynon, Jim - HORTICULTURE RESEARCH INT
item Chapman, Jarrod - DOE JOINT GENOME INST
item Damasceno, Cynthia - CORNELL UNIVERSITY
item Dorrance, Anne - THE OHIO STATE UNIVERSITY
item Dou, Daolong - VIRGINIA POLYTECHNIC INST
item Dickerman, Allan - VIRGINIA POLYTECHNIC INST
item Dubchak, Inna - DOE JOINT GENOME INST
item Garbelotto, Matteo - UC BERKELEY
item Gijzen, Mark - AGRICULTURE & AGRI-FOOD
item Gordon, Stuart - THE OHIO STATE UNIVERSITY
item Govers, Francine - WAGENINGEN UNIVERSITY
item Grunwald, Niklaus
item Huang, Wayne - DOE JOINT GENOME INST
item Ivors, Kelly - UC BERKELEY
item Jones, Richard
item Kamoun, Sophien - THE OHIO STATE UNIVERSITY
item Krampis, Konstantinos - VIRGINIA POLYTECHNIC INST
item Lamour, Kurt - UNIVERSITY OF TENNESSEE
item Lee, Mi-Kyung - TEXAS A&M UNIVERSITY
item Maclean, Donald - UNIVERSITY OF QUEENSLAND
item Mcdonald, W - OAK RIDGE NATIONAL LAB
item Medina, Monica - UC MERCED
item Meiger, Harold - WAGENINGEN UNIVERSITY
item Morris, Paul - BOWLING GREEN STATE UNIV
item Nordberg, Eric - VIRGINIA POLYTECHNIC INST
item Ospina-Giraldo, Manuel - WILKES UNIVERSITY
item Phuntumart, Vipaporn - BOWLING GREEN STATE UNIV
item Putnam, Nicholas - DOE JOINT GENOME INST
item Rash, Sam - DOE JOINT GENOME INST
item Rose, Jocelyn - CORNELL UNIVERSITY
item Sakihama, Yasuko - HOKKAIDO UNIVERSITY
item Salamov, Asaf - DOE JOINT GENOME INST
item Savidor, Alon - UNIVERSITY OF TENNESSEE
item Scheuring, Chantel - TEXAS A&M UNIVERSITY
item Smith, Brian - VIRGINIA POLYTECHNIC INST
item Sobral, Bruno - VIRGINIA POLYTECHNIC INST
item Terry, Astrid - DOE JOINT GENOME INST
item Torto-Alalibo, Trudy - VIRGINIA POLYTECHNIC INST
item Win, Joe - THE OHIO STATE UNIVERSIST
item Xu, Zhanyou - TEXAS A&M UNIVERSITY
item Zhang, Hongbin - TEXAS A&M UNIVERSITY
item Grigoriev, Igor - DOE JOINT GENOME INST
item Rokhsar, Daniel - DOE JOINT GENOME INST
item Boore, Jeffrey - DOE JOINT GENOME INST

Submitted to: Science
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: July 18, 2006
Publication Date: September 1, 2006
Citation: Tyler, B.M., Tripathy, S., Zhang, X., Dehal, P., Jiang, R.H., Aerts, A., Arredondo, F.D., Baxter, L., Bensasson, D., Beynon, J.L., Chapman, J., Damasceno, C.M., Dorrance, A.E., Dou, D., Dickerman, A.W., Dubchak, I.L., Garbelotto, M., Gijzen, M., Gordon, S.G., Govers, F., Grunwald, N.J., Huang, W., Ivors, K.L., Jones, R.W., Kamoun, S., Krampis, K., Lamour, K.H., Lee, M., Maclean, D.J., Mcdonald, W.H., Medina, M., Meiger, H.J., Morris, P.F., Nordberg, E.K., Ospina-Giraldo, M.D., Phuntumart, V., Putnam, N.H., Rash, S., Rose, J.K., Sakihama, Y., Salamov, A.A., Savidor, A., Scheuring, C.F., Smith, B.M., Sobral, B.W., Terry, A., Torto-Alalibo, T.A., Win, J., Xu, Z., Zhang, H., Grigoriev, I.V., Rokhsar, D.S., Boore, J.L. 2006. Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis. Science. 313:1261-1266.

Interpretive Summary: Phytophthora pathogens are among the most notorious and economically important plant pathogens known to mankind. Among these we count the potato late blight pathogen, Phytophthora infestans, responsible for causing the Irish potato famine and the Sudden Oak Death (SOD) pathogen, Phytophthora ramorum, responsible for large scale mortality in West coast oak forests. The whole genome sequences of two Phytophthora pathogens, namely the soybean pathogen P. sojae and the SOD pathogen P. ramorum, were contrasted. The genome sequences of P. sojae and P. ramorum have yielded novel and important insights into both the evolution of this group of eukaryotes most closely related to algae and their potential mechanisms of pathogenicity. The genomes reveal that the pathogens contain many hundreds of rapidly evolving genes encoding pathogenicity factors involved in disease establishment and development. In addition, this work also provided the opportunity for development of molecular tools to monitor the migration and evolution of the SOD pathogen that is crucial to management of the SOD epidemic.

Technical Abstract: Draft genome sequences of the soybean pathogen Phytophthora sojae and the sudden oak death pathogen Phytophthora ramorum have been determined to depths of 9x and 7.7x, respectively. Oomycetes such as these Phytophthora species share the kingdom Stramenopiles with photosynthetic algae such as diatoms, and the Phytophthora sequences suggest that the kingdom's ancestor harbored a photosynthetic endosymbiont. Comparison of the two species' genomes reveals a rapid expansion and diversification of protein families associated with plant infection such as hydrolases, ABC transporters, protein toxins, proteinase inhibitors and in particular a superfamily of 700 proteins with similarity to known oomycete avirulence genes.

Last Modified: 8/21/2014
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