Technical Abstract: Seed coat fragments that remain in the lint after the ginning process cause problems during the spinning process and ultimately affect the quality of finished goods. An experiment was conducted to determine the interactions of harvesting and saw ginning with a high-yielding high-quality cultivar that has a fragile seed coat. Four harvester treatments examined the effects of spindle size (diameter) and spindle speed. One of the harvester treatments contained a control cultivar. Four ginning treatments examined the effects of seed roll density and processing rate. The experiment affirmed that the cultivar with a fragile seed coat had many desirable fiber properties, but seed coat nep count and visible foreign matter content were not favorable. Results showed that short fiber content and length uniformity were better with the 16-mm (5/8-inch) spindle, maturity and immature fiber content were better with the 13-mm (1/2-inch) spindle, and seed coat nep count worsened when the 16-mm (5/8-inch) spindle ran at high speed. The paddle-roll seed roll box had the lowest amount of seed coat nep count and visible foreign matter content, and the standard and conveyor-tube roll boxes had the lowest amount of short fiber content.