Technical Abstract: Irrigation with reclaimed water from municipal wastewater treatment plants and wastewater from municipal and agricultural sources is becoming more widespread and adopted. The design and operation of irrigation systems utilizing wastewater and reclaimed water has some very important differences from irrigation systems designed and operated to apply water from potable or first-use water sources. The differences arise due to the constituents of the wastewater and reclaimed water, primarily as these constituents degrade human health and the environment. The design and operation principles also apply when the irrigation source is a surface water supply with degraded quality. In this review, we discuss the chemical, biological, and physical constituents of wastewater and reclaimed water; consider the crops suitable for irrigation with such waters; and discuss crop and irrigation system design issues.