|Haydon, Keith - PRINCE AGRI PRODS, INC.|
Submitted to: American Society of Animal Science Annual Meeting
Publication Type: Abstract Only
Publication Acceptance Date: February 27, 2006
Publication Date: July 9, 2006
Citation: Carroll, J.A., Haydon, K. 2006. Non-nutrient additives alter the weaned pig's stress and immune responses to a mycoplasma hyponeumoniae vaccination [abstract]. Journal of Animal Science. 84:307(Suppl. 1). Abstract #W20. Technical Abstract: Previously, we demonstrated that the acute phase response of weaned pigs following a lipopolysaccharide challenge can be altered with non-nutrient additives. The current objective was to evaluate three non-nutrient additives as potential modulators of the stress and immune responses of pigs following vaccination for Mycoplasma hyponeumoniae. Pigs (n=32; 6.3 + or - 0.1 Kg) were weaned at 21.4 + or - 0.3 d and moved to an off-site nursery where they were weighed, blocked by BW, and assigned to one of four treatment groups: 1) Control pigs (Cont; n=8) fed a non-medicated starter ration, 2) Pigs supplemented with 0.4% of experimental blend B (Exp B, n=8), 3) Pigs supplemented with 0.4% of experimental blend C (Exp C, n=8), and 4) Pigs supplemented with 0.4% NeutroMAX (NM, n=8). NM is a proprietary blend (patent pending) with proven immune enhancing properties. Exp B and Exp C are experimental 'next generation' NM blends. Pigs were individually housed and fed ad libitum for 10 d. Feed intake and BW were collected on d 5 and 10. On d 10, all pigs were non-surgically fitted with an indwelling jugular catheter. On d 11, all pigs received an i.m. dose (2 mL) of a Mycoplasma hyponeumoniae vaccine (RESPISURE-ONE®) at time 0 and blood samples collected at 30-min intervals from -2 h until 6 h, and then at 24 h. Catheters were removed and the pigs maintained on their respective diets for an additional 13 d. Blood samples were collected on d 7 and 14 post-vaccination via venipuncture. Whole blood samples were utilized for hematological measurements and serum samples were analyzed for cortisol. ADG prior to vaccination was greater (P < 0.04) in the NM and Exp B groups compared to the Cont group. However, post-vaccination growth was similar in all groups. Prior to vaccination, lymphocyte (P < 0.08) and neutrophil (P < 0.01) cell counts were higher in the Exp B and Exp C groups compared to the Cont group. During the first 24 h post-vaccination, serum cortisol was greater (P < 0.02) in the Cont group compared to all other groups. These data clearly demonstrate that non-nutrient additives can significantly affect the weaned pig's response to vaccination.