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United States Department of Agriculture

Agricultural Research Service

Title: Duration of Immunity to the 2002-03 California Virulent Newcastle Disease Virus (Vndv) Following a Single Newcastle Disease Vaccination of Spf Chickens

item Kapczynski, Darrell
item King, Daniel

Submitted to: American Association of Avian Pathologists
Publication Type: Abstract Only
Publication Acceptance Date: January 17, 2006
Publication Date: July 19, 2006
Citation: Kapczynski, D.R., King, D.J. 2006. Duration of immunity to the 2002-03 california virulent Newcastle disease virus (VNDV) following a single newcastle disease vaccination of SPF chickens [abstract]. American Association of Avian Pathologists. p. 80.

Technical Abstract: Newcastle disease (ND) vaccination is widely practiced in the USA with the majority of commercial chickens receiving multiple vaccinations during their lifetime. The objectives of the present study were to extend the knowledge of onset and duration of immunity of ND vaccines in specific-pathogen-free (SPF) chickens to a lethal challenge with the California 2002-03 virulent NDV (vNDV). Birds were vaccinated at 2 weeks-of-age with either a commercial live or inactivated NDV B1 vaccine. Groups of birds were challenged weekly from 3 to 8 weeks-of-age with vNDV. Vaccination with live or inactivated NDV B1 provided nearly complete protection of all challenged birds, whereas sham-vaccinated chickens were completely susceptible to challenge. Cloacal and oropharyngeal swabs were collected and tested by virus isolation. The results indicate, in the absence of maternal antibodies, single vaccination with either live or inactivated NDV B1 vaccines prevented most all morbidity and mortality following lethal vNDV challenge.

Last Modified: 4/18/2015
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