Submitted to: American Association of Avian Pathologists
Publication Type: Abstract Only
Publication Acceptance Date: January 17, 2006
Publication Date: July 9, 2006
Citation: Day, J.M., Pantin Jackwood, M.J., Spackman, E. 2006. Evidence of immune system dysfunction in poults infected with turkey-origin reoviruses. In: American Association of Avian Pathologists Annual Meeting Scienfitic Program, July 16-19, 2006, Honolulu, HI. 2006 CDROM. Technical Abstract: Recently, several avian orthoreoviruses have been isolated from commercial turkeys affected by Poult Enteritis Complex (PEC), a disease syndrome with uncertain etiology. Molecular characterization has shown that these turkey-origin reoviruses (TRVs) are unique among avian orthoreoviruses. The effect of a particularly pathogenic TRV strain on poult cell-mediated and humoral immunity was evaluated using a phytohemaglutanin toe-web inflammation assay and by measuring antibody response to Newcastle Disease Virus vaccine, respectively. The results of these assays suggest that TRV infection can lead to poult immune-dysfunction and may predispose poults to subsequent infections associated with the PEC disease state.