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United States Department of Agriculture

Agricultural Research Service

Title: Use of Protease Inhibitors to Reduce the Prevalence of Antibiotic Resistant Bacteria in Swine Manure

Authors
item Kumar, Kuldip - UNIVERSITY OF MINNESOTA
item Baidoo, Samuel - UNIVERSITY OF MINNESOTA
item Chander, Yogesh - UNIVERSITY OF MINNESOTA
item Gupta, Satish - UNIVERSITY OF MINNESOTA
item Rosen, Carl - UNIVERSITY OF MINNESOTA
item Russelle, Michael

Submitted to: ASA-CSSA-SSSA Annual Meeting Abstracts
Publication Type: Abstract Only
Publication Acceptance Date: November 1, 2005
Publication Date: November 1, 2005
Citation: Kumar, K., Baidoo, S.K., Chander, Y., Gupta, S.C., Rosen, C., Russelle, M.P. 2005. Use of protease inhibitors to reduce the prevalence of antibiotic resistant bacteria in swine manure [abstract]. ASA-CSSA-SSSA Annual Meeting Abstracts. CD-ROM. Paper No. 1944.

Technical Abstract: Antibiotics are fed to food animals at sub therapeutic levels for growth promotion. However, this practice leads to increases in antimicrobial resistance in the environment. Elimination or reduction in antibiotic use increases the potential for animal mortality as well as slower weight gain. In this paper we describe a study on the use of protease inhibitor as an alternative to antibiotics in swine production. Growth of 18 days old pigs for 1 month on protease inhibitor along with some antibiotics was significantly higher than the control pigs as well as the pigs on antibiotics alone. Furthermore, there was less antimicrobial resistance in the manure from pigs fed with protease inhibitor and antibiotics. We conclude that fine-tuning of protease inhibitor dose could significantly reduce antibiotic use in swine production as well as reduce antimicrobial resistance in the environment.

Last Modified: 7/25/2014
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