ARS | Publication request: PHAEOFURANS AND SORBICILLIN ANALOGS FROM A FUNGICOLOUS PHAEOACREMONIUM SPECIES (NRRL 32148)

Submitted to: Journal of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: December 9, 2005
Publication Date: January 6, 2006
Citation: Reategui, R.F., Wicklow, D.T., Gloer, J.B. 2006. Phaeofurans and sorbicillin analogs from a fungicolous Phaeoacremonium species (NRRL 32148). Journal of Natural Products. 69:113-117.

Interpretive Summary: Fungi that parasitize and kill other fungi offer a potential source of novel antifungal agents useful to agriculture and medicine. A previously undescribed species of Phaeoacremonium NRRL 32148, encountered as a colonist and potential parasite of the wood decay fungus Hypoxylon truncatum, collected at Chehaw Park in Albany, Georgia, was examined for its ability to produce antifungal agents and other bioactive metabolites. Phaeofurans are reported as new metabolites for which the closest known analog is integrasone, a recently reported HIV-integrase inhibitor. Sorbicillin analogs showed antifungal activity against Aspergillus flavus and Fusarium verticillioides.

Technical Abstract: Two new benzofuran-derived metabolites of polyketide origin called phaeofurans A and B (1–2), along with three sorbicillin analogs (3–5) have been obtained from a fungicolous isolate of the genus Phaeoacremonium (NRRL 32148). The structures were determined by analysis of MS and 2D NMR data. The antifungal effects of the extract were ascribed to the sorbicillin analogs.