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United States Department of Agriculture

Agricultural Research Service

Title: The Effect of Bio-Converted Polyunsaturated Fatty Acids on the Oxidation of Tag Containing Highly Unsaturated Fatty Acids

Authors
item Kim, Young-Mi - KYUNGPOOK NATL UNIV KOREA
item Lee, Geon-Ho - KYUNGPOOK NATL UNIV KOREA
item Yeo, Young-Guen - KYUNGPOOK NATL UNIV KOREA
item Kim, In-Hwan - KOREA UNIVERSITY SEOUL
item Miyashita, Kazuo - KOKKAIDO UNIV JAPAN
item Hou, Ching
item Kang, Sun-Chul - DAEGU UNIV KOREA
item Kim, Hak-Ryul - KYUNGPOOK NATL UNIV KOREA

Submitted to: Journal of Industrial Microbiology and Biotechnology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: August 15, 2005
Publication Date: January 15, 2006
Citation: Kim, Y., Lee, G., Yeo, Y., Kim, I., Miyashita, K., Hou, C.T., Kang, S., Kim, H. 2006. The effect of bio-converted polyunsaturated fatty acids on the oxidation of tag containing highly unsaturated fatty acids. Journal of Industrial Microbiology and Biotechnology. 33:17-21.

Interpretive Summary: Hydroxy fatty acids are considered to be important industrial materials because the hydroxyl group on fatty acids gives them special properties such as higher viscosity and reactivity, compared with non-hydroxylated fatty acids. Microbial modification of vegetable fatty acids can often lead to special changes in their structure and in biological function. Previously, we reported that a bacterial strain, Pseudomonas aeruginosa PR3, was able to convert oleic acid to mono- and di-hydroxy fatty acids and linoleic acid to trihydroxy fatty acids. In an effort to understand the overall mechanism involved in the varied biological functions of the complicated metabolites of bio-converted polyunsaturated fatty acids, we performed bioconversion of several polyunsaturated fatty acids using PR3 and determined their oxidative activities against fish oil. Until now, however, mechanisms by which those oxidized or hydroxy lipids exert antimicrobial and/or anticancer activities have not been clearly verified. We found that bio-converted linoleic acid, eicosapentanoic acid, and docosahexanoic acid promoted effectively oxidation of fish oil, assuming that this oxidative effect could plausibly play an important role in the antimicrobial function of these bio-converted fatty acids.

Technical Abstract: Microbial modification of vegetable fatty acids can often lead to special changes in their structure and in biological function. A bacterial strain, Pseudomonas aeruginosa PR3, is known to generate multiple hydroxylation on polyunsaturated fatty acids containing 1,4-cis,cis diene structural unit, obtaining antibacterial activity. In this paper, in an effort to understand the overall mechanism involved in the varied biological functions of the complicated metabolites of bio-converted polyunsaturated fatty acids, we performed bioconversion of several polyunsaturated fatty acids using PR3 and determined their oxidative activities against fish oil. Bio-converted linoleic acid, eicosapentanoic acid, and docosahexanoic acid promoted effectively oxidation of fish oil, assuming that this oxidative effect could plausibly play an important role in the antimicrobial function of these bio-converted fatty acids.

Last Modified: 10/1/2014
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