|Kim, J - IOWA STATE UNIVERSITY|
|Zhao, S - IOWA STATE UNIVERSITY|
|Uthe, J - IOWA STATE UNIVERSITY|
|Tuggle, C - IOWA STATE UNIVERSITY|
Submitted to: Cytogenetics and Genome Research
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: September 8, 2005
Publication Date: February 1, 2006
Citation: Kim, J.W., Zhao, S.H., Uthe, J.J., Bearson, S.M., Tuggle, C.K. 2006. Assignment of the scavenger receptor class B, member 2 gene (SCARB2) to porcine chromosome 8q11-->q12 by somatic cell and radiation hybrid panel mapping. Cytogenetics and Genome Research. 112(3-4):342H. Interpretive Summary: Disease resistance has genetic heritability; therefore, identifying genes that control an animal’s resistance (or susceptibility) to an infectious disease is an important step towards infection control. We mapped a gene identified as having elevated gene expression within the mesenteric lymph nodes of swine during infection with Salmonella enterica serotype Choleraesuis. As this gene contributes to the host’s response to Salmonella infection, it could be useful in improving disease resistance through marker-assisted selection.
Technical Abstract: The identification of genes controlling infectious disease is an important step towards increasing disease resistance in the pig. Infectious diseases increase the cost of production, and, for zoonotic pathogens, also impact food safety. Disease resistance has genetic heritability, and the mapping of genes involved in natural resistance (innate immunity) has been reported. Quantitative trait loci (QTLs) for immune parameters and immune capacity traits have been reported. The objective of this research was to map gene identified as having altered gene expression patterns within the mesenteric lymph nodes of swine during infection with Salmonella enterica serotype Choleraesuis. The SCARB2 gene has been shown to increase RNA expression within 24 hours post-infection, and was identified using Suppression Subtractive Hybridization (SSH). Overall, this gene is an excellent candidate for participating in the host response to infection and could therefore be useful in improving disease resistance through marker-assisted selection.