Technical Abstract: Forty-two accessions were randomly selected from the Ethiopian sorghum collection maintained by the USDA, ARS National Plant Germplasm System and evaluated for anthracnose disease response during the 2004 dry and wet growing seasons in Isabela, Puerto Rico. A resistant response was observed for 20 accessions with 13 accessions susceptible to the disease for the two growing seasons. Nine accessions showed variation in infection response within and between growing seasons. Approximately 80% of the accessions showed a similar disease response for the two growing seasons. This would suggest that large-scale evaluations could be conducted throughout the year in Puerto Rico to screen the more than 7,000 Ethiopian accessions in the collection for the identification of anthracnose resistant germplasm.