Submitted to: Veterinary Pathology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: September 14, 2005
Publication Date: May 1, 2006
Citation: Hamir, A.N., Kunkle, R.A., Miller, J.M., Hall, S.M. 2006. Abnormal prion protein in ectopic lymphoid tissue in a kidney of an asymptomatic white-tailed deer experimentally inoculated with the agent of chronic wasting disease. Veterinary Pathology. 43(3):367-369. Interpretive Summary: Chronic wasting disease (CWD) is a fatal disease of brain and spinal cord of deer and elk. It belongs to a group of transmissible spongiform encephalopathy (TSE) diseases which includes bovine spongiform encephalopathy or "mad cow disease". Infection by the CWD agent induces accumulations of an abnormal form of protein (called prion or PrP**res) in tissues of nervous and lymphoid systems. This report documents presence of PrP**res within kidney of a white tailed deer that was experimentally inoculated by intracerebral route with CWD. The deer was euthanized and examined at 10 months post inoculation. At that age it did not show any clinical signs of the disease but lesions of TSE were detected in the tissues. These findings confirm early involvement of tissues in white tailed deer. Also, it corroborates the recently published finding of presence of PrP**res in organs other than brain and lymphoid systems in laboratory animals with TSE (scrapie) by demonstration of the same phenomenon in a natural host species.