|Kim, H - TIGR ROCKVILLE MD|
|Nierman, William - TIGR ROCKVILLE MD|
|Kim, Jong Heon|
Submitted to: International Union of Microbiological Societies Proceedings/Abstracts
Publication Type: Abstract Only
Publication Acceptance Date: April 30, 2005
Publication Date: July 30, 2005
Citation: Yu, J., Wilkinson, J.R., Kim, H.S., Nierman, W.C., Kim, J.H., Campbell, B.C., Bhatnagar, D., Cleveland, T.E. 2005. Aspergillus flavus genomics for studying the mechanism of aflatoxin biosynthesis. International Union of Microbiological Societies (IUMS) Proceedings/Abstracts, July 23-28, 2005, San Francisco, CA. p. 6. Technical Abstract: Aflatoxins are secondary metabolisms produced by the molds, Aspergillus flavus and A. parasiticus. These compounds are toxic and extremely carcinogenic. It poses a serious health hazard when they contaminate food and feed commodities. Sequencing and annotation of A. flavus ESTs identified 7,218 unique EST sequences. Genes that are putatively involved in aflatoxin biosynthesis, regulation and signal transduction, fungal virulence or pathogenicity, stress response or antioxidation, and fungal development were identified from these ESTs. Gene profiling under aflatoxin-producing and non-producing conditions has thus far identified hundreds of genes that are potentially involved in aflatoxin production. Further investigations on the functions of these genes are underway. This research is expected to provide information for developing new strategies for control of aflatoxin contamination of agricultural commodities.