Hometop nav spacerAbout ARStop nav spacerHelptop nav spacerContact Ustop nav spacerEn Espanoltop nav spacer
Printable VersionPrintable Version     E-mail this pageE-mail this page
United States Department of Agriculture Agricultural Research Service
Search
 
 
 
National Programs
International Programs
Find Research Projects
The Research Enterprise
Office of Scientific Quality Review
Research Initiatives
 
You are here: Research /

Title: SEQUENCING AND MAPPING OF THE BOVINE TYPE II DEIODINASE (DIO2) AND TYPE III DEIODINASE (DIO3) GENES

Authors
item Connor, Erin
item Laiakis, E
item Fernandes, Violet
item Williams, J - ROSLIN INSTITUTE

Submitted to: Germplasm Release
Publication Type: Germplasm Release
Publication Acceptance Date: December 29, 2004
Publication Date: January 1, 2005
Citation: Connor, E.E., Laiakis, E.C., Fernandes, V.M., Williams, J.L. 2005. Sequencing and mapping of the bovine type ii deiodinase (dio2) and type iii deiodinase (dio3) genes. Germplasm Release. Accession numbers AY858551-AY858554.

Technical Abstract: Thyroid hormones are critical to normal mammalian development and metabolism. Their activity is regulated in a highly complex, tissue-specific manner by three isoforms of deiodinases. The full-length bovine type II deiodinase (DIO2) and type III deiodinase (DIO3) cDNAs were sequenced revealing a high degree of predicted amino acid sequence identity to their orthologs in other mammalian species and demonstrated the conservation of selenocysteine residues within the catalytic domains of both bovine proteins. In addition, three single nucleotide polymorphisms and one indel were identified in the bovine DIO2 transcript. Bovine DIO2 and DIO3 were positioned on chromosomes 10 and 21, respectively, by radiation hybrid mapping.

   
 
 
Last Modified: 05/25/2013
ARS Home | USDA.gov | Site Map | Policies and Links 
FOIA | Accessibility Statement | Privacy Policy | Nondiscrimination Statement | Information Quality | USA.gov | White House