ARS | Publication request: FLAVONOIDS AND THE BRAIN: INTERACTIONS AT THE BLOOD BRAIN BARRIER AND THEIR PHYSIOLOGICAL EFFECT ON THE CNS

Submitted to: Free Radical Biology and Medicine
Publication Type: Review Article
Publication Acceptance Date: August 5, 2004
Publication Date: September 11, 2004
Citation: Youdim, K.A., Shukitt Hale, B., Joseph, J.A. 2004. Flavonoids and the brain: interactions at the blood brain barrier and their physiological effect on the cns. Free Radical Biology and Medicine, VOL 37, NO11 PP. 1683-1693.

Technical Abstract: Over the past few years there has been an exponential growth in the number of reports describing the effects of nutritional modulation on ageing and age-related diseases. Specific attention has been directed towards the beneficial effects afforded by dietary antioxidants, in particular those from fruit and vegetables, at ameliorating age-related deficits in brain performance. The rationale for studying the effects of dietary intervention stems from evidence implicating free radicals in the aspects related to the ageing process. Age-dependent neuropathology is a cumulative response to alterations induced by reactive oxygen species. Therefore cognitive ageing, according to this hypothesis, should be slowed, and possibly even reversed, by appropriately increasing levels of antioxidants, or decreasing overproduction of free radicals, in the body