ARS | Publication request: THE EFFECT OF NICKEL DEPRIVATION ON BONE STRENGTH AND SHAPE AND URINARY PHOSPHORUS EXCRETION IS NOT ENHANCED BY A MILD MAGNESIUM DEPRIVATION IN RATS

Submitted to: Workshop Proceedings
Publication Type: Proceedings
Publication Acceptance Date: September 1, 2004
Publication Date: November 1, 2004
Citation: Nielsen, F.H. 2004. The effect of nickel deprivation on bone strength and shape and urinary phosphorus excretion is not enhanced by a mild magnesium deprivation in rats. In: Anke, M., Flachowsky, G., Kisters, K., Schafer, U., Schenkel, H., Seifert, M., Stoeppler, M., editors. Proceedings of the Macro and Trace Elements 22nd Workshop, September 24-25, 2004, Jena, Germany. 2:965-70.

Technical Abstract: Among the first reported signs of nickel (Ni) deprivation were changes in calcium (Ca) metabolism and bone structure and composition. These signs included thickened legs, swollen hock joints, and a reduced tibia length/width ratio in chicks (Nielsen and Sauberlich, 1970); increased renal excretion of Ca and decreased Ca concentration in the skeleton of mini-pigs (Anke et al, 1974); and an increased magnesium (Mg) concentration in femurs of rats (Kirchgessner et al, 1980). More recently, Wilson et al (2001) reported that a relatively high Ni supplementation (25 mg/kg diet) increased strength variables (shear force, stress and fracture energy) of the radius, but did not affect percent ash (a measure of bone density) in tibias of broilers. The finding that Ni deprivation increased the Mg content of bone and other findings suggesting a relationship between Ni and Mg that could affect the skeletal system (Kenney and McCoy, 1992) prompted an experiment with rats to test the hypothesis that Ni deprivation alters bone strength, structure and composition through altering Mg metabolism or utilization.