|Kehrli Jr, Marcus|
Submitted to: Pig Veterinary Society International Congress Proceedings
Publication Type: Proceedings
Publication Acceptance Date: February 28, 2004
Publication Date: June 27, 2004
Citation: Wesley, R.D., Lager, K.M., Kehrli, Jr., M.E. 2004. PRRSV infection stimulates an immediate serum interferon-gamma response. In: Proceedings of the 18th Congress of the International Pig Veterinary Society (IPVS) Congress, June 27-July 2, 2004, Hamburg, Germany. p. 90. Technical Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) infects swine macrophages. The humoral immune reponse in terms of anti-PRRSV neutralizing antibodies is weak. Apparently, cellular immunity to PRRSV infection is also gradual. A central component for cellular (Th-1 type) immunity is interferon-gamma (IFN-gamma). Therefore, to better understand the pig's Th-1 reponse to PRRSV infection, we have investigated serum IFN-gamma levels and the duration of viremia following the infection of weaned pigs with 2 strains of atypical PRRSV.