Submitted to: American Association of Immunologists Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: April 10, 2004
Publication Date: May 2, 2004
Citation: Lillehoj, H.S., Min, W. 2004. High-throughput gene expressiion profiling of host intstinal immune response to eimeria.. American Association of Immunologists Proceedings p. 212.
Avian coccidiosis is caused by several Eimeria strains which infect different regions of the intestine inducing a strain-specific immunity. Coccidiosis usually stimulate a number of immunological defense mechanisms, namely both antibody- and cell-mediated. Recent technological advances in high-throughput molecular approaches to identify disease resistance genes and molecular/cell biological pathways associated with complex biological phenomenon now enable a comprehensive investigation of host protective immune mechanisms. Our recent studies on local host immunity to Eimeria clearly indicate that intricate and complex interactions of host local cell-mediated immunity and parasites determine the outcome of host response to coccidiosis. High-throughput gene expression profiling and real-time PCR have been applied to analyze underlying immune mechanisms controlling disease resistance/susceptibility to coccidiosis. The results indicate role of various cytokines in controlling host intestinal innate immune response to Eimeria.