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Title: DEVELOPMENT OF AN INACTIVATED NEWCASTLE DISEASE VIROSOME VACCINE THAT PROTECTS AGAINST CHALLENGE FROM VELOGENIC TEXAS GB

Author
item Kapczynski, Darrell
item Tumpey, Terrence

Submitted to: Immunology Research Workshop
Publication Type: Abstract Only
Publication Acceptance Date: 10/10/2003
Publication Date: 12/2/2003
Citation: Kapczynski, D.R., Tumpey, T. 2003. Development of an inactivated newcastle disease virosome vaccine that protects against challenge from velogenic texas gb. Immunology Research Workshop.

Interpretive Summary:

Technical Abstract: While outbreaks of highly virulent Newcastle disease virus (NDV) are a major concern to the poultry industry internationally, economic losses caused by low virulent (lentogenic) strains continue to result from decreased egg production in layers and airsacculitis in broilers. Since lentogenic strains of NDV are widely used as vaccine strains, it is possible that these viruses, may be directly or indirectly responsible for some of the economic losses. In an effort to examine protection against NDV, we developed a non-replicating virosome vaccine that retains the ability to hemagglutinate chicken red blood cells and fuse with chicken embryo cells. Preliminary vaccine efficacy studies indicate that two intranasal doses containing 10 'g of virosomes protects chickens against lethal challenge from velogenic Texas GB.