Submitted to: Plant and Animal Genome Conference Proceedings
Publication Type: Proceedings
Publication Acceptance Date: December 1, 2003
Publication Date: January 14, 2004
Citation: Connor, E.E., Sonstegard, T.S., Ashwell, M.S., Bennett, G.L., Williams, J.L. 2004. Chromosomal mapping of 12 gene-associated markers in cattle identifies novel regions of conserved synteny between the human and bovine genomes. Plant and Animal Genome XII:228. Abstract P630.
Current gene density on the bovine genetic maps is extremely limited and the resolution of the human-bovine comparative map is insufficient for selection of positional candidate genes controlling many economic traits of interest in dairy cattle. This study describes the chromosomal mapping of 12 gene-associated markers to bovine linkage and radiation hybrid maps to improve the breakpoint resolution in the human-bovine comparative map near two previously identified quantitative trait loci for the conformation trait, dairy form. Two novel regions of conserved synteny were identified between the telomeric region of bovine chromosome 27 (BTA27) and the p24 region of human chromosome 3 (HSA3) and between the HSA4q34.1 region and BTA8. These data increase the number of genes positioned on the bovine genetic maps, refine the human-bovine comparative map, and should improve the efficiency of positional candidate gene selection for the dairy form trait in cattle.