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United States Department of Agriculture

Agricultural Research Service

Title: Linkage Mapping of Four Chicken Calpain Genes

Authors
item Okumura, F - KAGOSHIMA UNIVERSITY
item Shimogiri, T - KAGOSHIMA UNIVERSITY
item Shinbo, Y - KAGOSHIMA UNIVERSITY
item Yoshizawa, K - KOBE UNIVERSITY
item Kawabe, K - KAGOSHIMA UNIVERSITY
item Mannen, H - KOBE UNIVERSITY
item Okamoto, S - KAGOSHIMA UNIVERSITY
item Cheng, Hans
item Maeda, Y - KAGOSHIMA UNIVERSITY

Submitted to: Journal of Animal Science Supplement
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: October 14, 2004
Publication Date: November 1, 2005
Citation: Okumura, F., Shimogiri, T., Shinbo, Y., Yoshizawa, K., Kawabe, K., Mannen, H., Okamoto, S., Cheng, H.H., Maeda, Y. 2005. Linkage mapping of four chicken calpain genes. Animal Science Journal. 76:121-127.

Interpretive Summary: Growth rate and meat quality are very important agronomic traits for the poultry and livestock industries. Calpains are a family of proteases (protein enzymes) known to influence muscle growth and turnover. In this paper, four calpain genes were mapped to specific location on chicken chromosomes. This information will help determine if calpain genes account for differences in growth and meat quality traits between various broiler (meat) chicken lines. Furthermore, the mapping of the calpain genes extends the coverage of the chicken genetic map, and the amount of observed conservation between the human and chicken genomes, which helps in identifying other chicken genes by virtue of their human counterparts.

Technical Abstract: Calpains are intracellular Ca2+ dependent proteases. In this study, we identified polymorphisms in four calpain genes (CAPN1, CAPN2, CAPN3, and CAPN1.5) expressed ubiquitously in chicken, and mapped them using two backcross families, East Lansing (EL) and Kobe University (KU)]. CAPN2 and CAPN1.5 mapped to two locations on GGA3 about 30 cM apart. CAPN2 extends the amount of conserved synteny with HSA1. CAPN3 mapped to GGA5, and this region was syntenic with HSA15. CAPN1 was linked to a previously unlinked microsatellite marker LEI0140 to form a new linkage group called E66.

Last Modified: 8/29/2014
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